Immunotherapy has recently become a promising cancer therapy with extensive applications of immune checkpoint inhibitors (ICIs).However, pancreatic ductal adenocarcinoma (PDAC) appears to be unresponsive to immunotherapy due to the immunosuppressive microenvironment.Recent studies showed that cancer stem cell marker DCLK1 promoted the initiation an

The accurate prediction of protein druggability (propensity to Automotive Test Equipment bind high-affinity drug-like small molecules) would greatly benefit the fields of chemical genomics and drug discovery.We have developed a novel approach to quantitatively assess protein druggability by computationally screening a fragment-like compound library

This is an editorial statement for the Journal of Education Research and Rural Community Development (JERRCD); the journal is releasing its inaugural publication.The article provided a brief background to the journal, and the research forum that birthed the Journal was situated, coupled with it meritorious promises for quality knowledge production.

Conflicts between national and local governments over land use in floodplains have been well documented in the Automotive Test Equipment US and elsewhere.The US National Flood Insurance Program offers subsidized flood insurance to communities that agree to prevent further development in floodplains, but the requirements are poorly enforced and loca

Advances of elemental analysis in geology are defined by the development and improvement ofphysical, instrumental methods of chemical analysis.New instrumental methods - emission spectrometry and mass spectrometry with inductively coupled plasma (ICP) sources are the most popular in the area of elemental analysis in recent years.These methods have